Overview
ZES is caused by gastrin-secreting tumors, usually in the pancreas or duodenum, leading to excessive acid production.
Symptoms
• Multiple ulcers
• Persistent heartburn
• Diarrhea
• Abdominal pain
• Weight loss
Diagnosis
• Gastrin blood levels
• Secretin stimulation test
• Endoscopy
• Imaging for tumors
Treatment
• High-dose PPIs
• Surgical removal of tumors
• Somatostatin analogs
• Managing complications
Self-Management
Tracking ulcer symptoms and reflux patterns helps monitor severity.