Overview
MCAS involves inappropriate mast cell activation, releasing histamine and other chemicals that affect multiple organs, including the gut.
Symptoms
• Abdominal pain
• Diarrhea
• Bloating
• Flushing
• Hives
• Palpitations
• Anaphylactoid episodes
Triggers
• Heat
• Stress
• High-histamine foods
• Alcohol
• Exercise
• Infections
Diagnosis
• Tryptase levels
• 24-hour urine tests
• Symptom patterns
Treatment
• H1 + H2 antihistamines
• Mast cell stabilizers
• Low-histamine diet
• Avoiding triggers
Self-Management
Tracking flares + food triggers is essential.